Late sodium current: A mechanism for angina, heart failure, and arrhythmia.
Trends Cardiovasc Med
; 26(2): 115-22, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26092781
ABSTRACT
The peak sodium current underlies excitability and conduction in heart muscle, but a late sodium current flowing after the peak contributes to maintaining and prolonging the action potential plateau, and also to intracellular sodium loading, which in turn increases intracellular calcium with consequent effects on arrhythmia and diastolic function. Late sodium current is pathologically increased in both genetic and acquired heart disease, making it an attractive target for therapy to treat arrhythmia, heart failure, and angina. This review provides an overview of the underlying bases for the clinical implications of late sodium current block.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
/
Canales de Sodio
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Insuficiencia Cardíaca
/
Angina de Pecho
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article