Potential Prepore Trimer Formation by the Bacillus thuringiensis Mosquito-specific Toxin: MOLECULAR INSIGHTS INTO A CRITICAL PREREQUISITE OF MEMBRANE-BOUND MONOMERS.

Sriwimol, Wilaiwan; Aroonkesorn, Aratee; Sakdee, Somsri; Kanchanawarin, Chalermpol; Uchihashi, Takayuki; Ando, Toshio; Angsuthanasombat, Chanan

Sriwimol, Wilaiwan; Aroonkesorn, Aratee; Sakdee, Somsri; Kanchanawarin, Chalermpol; Uchihashi, Takayuki; Ando, Toshio; Angsuthanasombat, Chanan.

Sriwimol W; Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Nakornpathom 73170, Thailand; Department of Bacterial Protein Toxin Research Cluster, Institute of Molecular Biosciences, Mahidol University, Nakornpathom 73170, Thailand.
Aroonkesorn A; Department of Bacterial Protein Toxin Research Cluster, Institute of Molecular Biosciences, Mahidol University, Nakornpathom 73170, Thailand.
Sakdee S; Department of Bacterial Protein Toxin Research Cluster, Institute of Molecular Biosciences, Mahidol University, Nakornpathom 73170, Thailand.
Kanchanawarin C; Laboratory of Theoretical and Computational Biophysics, Department of Physics, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
Uchihashi T; Department of Physics and Bio-AFM Frontier Research Center, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
Ando T; Department of Physics and Bio-AFM Frontier Research Center, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
Angsuthanasombat C; Department of Bacterial Protein Toxin Research Cluster, Institute of Molecular Biosciences, Mahidol University, Nakornpathom 73170, Thailand; Laboratory of Molecular Biophysics and Structural Biochemistry, Biophysics Institute for Research and Development, Bangkok 10160, Thailand. Electronic address

J Biol Chem ; 290(34): 20793-20803, 2015 Aug 21.

Article en En | MEDLINE | ID: mdl-26112409

Asunto(s)

Bacillus thuringiensis/química; Proteínas Bacterianas/química; Toxinas Bacterianas/química; Endotoxinas/química; Proteínas Hemolisinas/química; Insecticidas/química; Células Sf9/efectos de los fármacos; Aedes/citología; Aedes/efectos de los fármacos; Animales; Bacillus thuringiensis/metabolismo; Toxinas de Bacillus thuringiensis; Proteínas Bacterianas/genética; Proteínas Bacterianas/toxicidad; Toxinas Bacterianas/genética; Toxinas Bacterianas/toxicidad; Dimiristoilfosfatidilcolina/química; Endotoxinas/genética; Endotoxinas/toxicidad; Escherichia coli/genética; Escherichia coli/metabolismo; Expresión Génica; Glucósidos/química; Proteínas Hemolisinas/genética; Proteínas Hemolisinas/toxicidad; Proteínas de Insectos/genética; Proteínas de Insectos/metabolismo; Insecticidas/metabolismo; Insecticidas/toxicidad; Liposomas/química; Micelas; Simulación de Dinámica Molecular; Control Biológico de Vectores; Conformación Proteica; Multimerización de Proteína; Receptores de Superficie Celular/genética; Receptores de Superficie Celular/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/toxicidad; Células Sf9/citología; Spodoptera/citología; Spodoptera/efectos de los fármacos; Ácidos Sulfónicos/química

Palabras clave

EM; bacillus; bacterial toxin; conformational transition; gel electrophoresis; high-speed atomic force microscopy; micelle-induced trimerization; propeller-like shape; protein assembly; three-dimensional reconstructed prepore

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bacillus thuringiensis / Proteínas Bacterianas / Toxinas Bacterianas / Endotoxinas / Células Sf9 / Proteínas Hemolisinas / Insecticidas Idioma: En Año: 2015 Tipo del documento: Article

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