Theory of a microfluidic serial dilution bioreactor for growth of planktonic and biofilm populations.
J Math Biol
; 72(5): 1401-27, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-26134670
ABSTRACT
We present the theory of a microfluidic bioreactor with a two-compartment growth chamber and periodic serial dilution. In the model, coexisting planktonic and biofilm populations exchange by adsorption and detachment. The criteria for coexistence and global extinction are determined by stability analysis of the global extinction state. Stability analysis yields the operating diagram in terms of the dilution and removal ratios, constrained by the plumbing action of the bioreactor. The special case of equal uptake function and logistic growth is analytically solved and explicit growth curves are plotted. The presented theory is applicable to generic microfluidic bioreactors with discrete growth chambers and periodic dilution at discrete time points. Therefore, the theory is expected to assist the design of microfluidic devices for investigating microbial competition and microbial biofilm growth under serial dilution conditions.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plancton
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Biopelículas
/
Reactores Biológicos
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Modelos Biológicos
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Año:
2016
Tipo del documento:
Article