A novel system for screening antiretroviral agents.
J Virol Methods
; 26(2): 229-35, 1989 Nov.
Article
en En
| MEDLINE
| ID: mdl-2613855
ABSTRACT
We propose a new screening system of drugs capable of inactivating retroviruses by interfering with the binding, entry into the cell, uncoating, reverse transcription, migration into the nucleus or integration of the retrovirus. It is based on the utilization of recombinant retroviruses which can be detected in single cells by the expression of a LacZ reporter gene. It allows simple and rapid quantification of the number of infectious viral particles. The screening system can then be used to precisely define the period sensitive to the drug.
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Banco de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Aziridinas
/
Evaluación Preclínica de Medicamentos
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Animals
Idioma:
En
Año:
1989
Tipo del documento:
Article