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Discovery of a novel 2,3,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinoline-1,4(6H)-dione series promoting neurogenesis of human neural progenitor cells.
Lin, Hong; Fang, Haiyan; Wang, Jamie; Meng, Qinghua; Dai, Xuedong; Wu, Sharon; Luo, Jie; Pu, Dan; Chen, Libo; Minick, Douglas; Arai, Ken; Mandeville, Emiri T; Lo, Eng; Holder, Julie C; Chuang, Tsu Tshen; Zhao, Jing.
  • Lin H; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. Electronic address: hong.2.lin@gsk.com.
  • Fang H; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Wang J; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Meng Q; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Dai X; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Wu S; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Luo J; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Pu D; Platform Technology and Science, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Chen L; Platform Technology and Science, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Minick D; Platform Technology and Science, GlaxoSmithKline, 5 Moore Drive, RTP, NC 27709, USA.
  • Arai K; Harvard Stem Cell Institute, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA.
  • Mandeville ET; Harvard Stem Cell Institute, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA.
  • Lo E; Harvard Stem Cell Institute, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA.
  • Holder JC; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Chuang TT; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Zhao J; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
Bioorg Med Chem Lett ; 25(17): 3748-53, 2015 Sep 01.
Article en En | MEDLINE | ID: mdl-26142946
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazinas / Relación Estructura-Actividad / Neurogénesis / Células-Madre Neurales / Isoquinolinas Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazinas / Relación Estructura-Actividad / Neurogénesis / Células-Madre Neurales / Isoquinolinas Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article