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FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.
Wang, Z; Dove, P; Wang, X; Shamas-Din, A; Li, Z; Nachman, A; Oh, Y J; Hurren, R; Ruschak, A; Climie, S; Press, B; Griffin, C; Undzys, E; Aman, A; Al-awar, R; Kay, L E; O'Neill, D; Trudel, S; Slassi, M; Schimmer, A D.
  • Wang Z; 1] Princess Margaret Cancer Centre, Toronto, ON, Canada [2] Fluorinov Pharma Inc., Toronto, ON, Canada.
  • Dove P; Fluorinov Pharma Inc., Toronto, ON, Canada.
  • Wang X; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Shamas-Din A; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Li Z; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Nachman A; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Oh YJ; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Hurren R; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Ruschak A; Department of Molecular Genetics, Biochemistry and Chemistry, University of Toronto, Toronto, ON, Canada.
  • Climie S; Fluorinov Pharma Inc., Toronto, ON, Canada.
  • Press B; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Griffin C; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Undzys E; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Aman A; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Al-awar R; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Kay LE; Department of Molecular Genetics, Biochemistry and Chemistry, University of Toronto, Toronto, ON, Canada.
  • O'Neill D; 1] Fluorinov Pharma Inc., Toronto, ON, Canada [2] Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Trudel S; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Slassi M; Fluorinov Pharma Inc., Toronto, ON, Canada.
  • Schimmer AD; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Cell Death Dis ; 6: e1815, 2015 Jul 09.
Article en En | MEDLINE | ID: mdl-26158521
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Inhibidores de Proteasoma / Flúor / Mieloma Múltiple / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Inhibidores de Proteasoma / Flúor / Mieloma Múltiple / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article