Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.
Cytokine Growth Factor Rev
; 26(5): 517-22, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26198769
ABSTRACT
Mutations in cardiotrophin-like cytokine factor (CLCF1) and the related cytokine to which it binds, cytokine receptor-like factor 1 (CRLF1), are associated with Crisponi/cold induced sweating syndromes, and lead to early neonatal death in mice due to a suckling defect. These cytokines are members of the IL-6 superfamily, and form a range of composite cytokines that signal through gp130 bound either to the ciliary neurotrophic factor receptor (CNTFR) or a complex that involves the IL-27 p28 subunit. This review describes current knowledge of the signalling complexes formed by these cytokines, and explores their described and suggested roles in the neural, haematopoietic, skeletal, renal, immune and respiratory systems during development and adulthood, and in degenerative diseases and cancer.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trismo
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Deformidades Congénitas de la Mano
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Citocinas
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Interleucina-6
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Fiebre
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Proteínas de Neoplasias
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article