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Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model.
Xia, Lei; Hong, Xin; Sakban, Rashidah Binte; Qu, Yinghua; Singh, Nisha Hari; McMillian, Michael; Dallas, Shannon; Silva, Jose; Sensenhauser, Carlo; Zhao, Sylvia; Lim, Heng Keang; Yu, Hanry.
  • Xia L; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9-04-11, 2 Medical Drive, 117597, Singapore.
  • Hong X; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9-04-11, 2 Medical Drive, 117597, Singapore.
  • Sakban RB; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9-04-11, 2 Medical Drive, 117597, Singapore.
  • Qu Y; Institute of Bioengineering and Nanotechnology, A*STAR, The Nanos, #04-01, 31 Biopolis Way, 138669, Singapore.
  • Singh NH; Institute of Bioengineering and Nanotechnology, A*STAR, The Nanos, #04-01, 31 Biopolis Way, 138669, Singapore.
  • McMillian M; Institute of Bioengineering and Nanotechnology, A*STAR, The Nanos, #04-01, 31 Biopolis Way, 138669, Singapore.
  • Dallas S; Preclinical Development & Safety, Janssen Research & Development, LLC, Spring House, PA, USA.
  • Silva J; Preclinical Development & Safety, Janssen Research & Development, LLC, Spring House, PA, USA.
  • Sensenhauser C; Preclinical Development & Safety, Janssen Research & Development, LLC, Spring House, PA, USA.
  • Zhao S; Preclinical Development & Safety, Janssen Research & Development, LLC, Spring House, PA, USA.
  • Lim HK; China R&D and Scientific Affairs, Janssen Research and Development, LLC, Shanghai, 200030, China.
  • Yu H; Preclinical Development & Safety, Janssen Research & Development, LLC, Spring House, PA, USA.
J Appl Toxicol ; 36(2): 320-9, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26201057
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Cultivadas / Hepatocitos / Sistema Enzimático del Citocromo P-450 / Evaluación de Medicamentos / Interacciones Farmacológicas / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Cultivadas / Hepatocitos / Sistema Enzimático del Citocromo P-450 / Evaluación de Medicamentos / Interacciones Farmacológicas / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article