Unique side effects of interferon.
J Pak Med Assoc
; 65(8): 895-7, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26228341
ABSTRACT
Interferon-alpha, a potent mediator of host immune response, has immunomodulatory properties in addition to its antiviral effects. A wide spectrum of autoimmune diseases can occur in patients treated with interferon-alpha for chronic hepatitis B and D, of which clinical systemic lupus erythematosus (SLE) accounts for less than 1% and hypothyroidism for 2-4 %. We report herein a case of a 16-year-old male who developed antinuclear antibody (ANA)-negative SLE and hypothyroidism after treatment with interferon-alpha for chronic hepatitis. High index of suspicion is therefore necessary in all patients treated with interferon for early diagnosis and treatment.
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Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Interferón-alfa
/
Hepatitis B Crónica
/
Hepatitis D Crónica
/
Hipotiroidismo
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Screening_studies
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Año:
2015
Tipo del documento:
Article