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Recanalization therapies in acute ischemic stroke patients: impact of prior treatment with novel oral anticoagulants on bleeding complications and outcome.
Seiffge, David J; Hooff, Robbert-JanVan; Nolte, Christian H; Béjot, Yannick; Turc, Guillaume; Ikenberg, Benno; Berge, Eivind; Persike, Malte; Dequatre-Ponchelle, Nelly; Strbian, Daniel; Pfeilschifter, Waltraud; Zini, Andrea; Tveiten, Arnstein; Næss, Halvor; Michel, Patrik; Sztajzel, Roman; Luft, Andreas; Gensicke, Henrik; Traenka, Christopher; Hert, Lisa; Scheitz, Jan F; De Marchis, Gian Marco; Bonati, Leo H; Peters, Nils; Charidimou, Andreas; Werring, David J; Palm, Frederick; Reinhard, Matthias; Niesen, Wolf-Dirk; Nagao, Takehiko; Pezzini, Alessandro; Caso, Valeria; Nederkoorn, Paul J; Kägi, Georg; von Hessling, Alexander; Padjen, Visnja; Cordonnier, Charlotte; Erdur, Hebun; Lyrer, Philippe A; Brouns, Raf; Steiner, Thorsten; Tatlisumak, Turgut; Engelter, Stefan T.
  • Seiffge DJ; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Hooff RJ; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Nolte CH; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Béjot Y; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Turc G; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Ikenberg B; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Berge E; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Persike M; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Dequatre-Ponchelle N; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Strbian D; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Pfeilschifter W; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Zini A; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Tveiten A; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Næss H; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Michel P; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Sztajzel R; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Luft A; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Gensicke H; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Traenka C; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Hert L; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Scheitz JF; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • De Marchis GM; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Bonati LH; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Peters N; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Charidimou A; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Werring DJ; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Palm F; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Reinhard M; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Niesen WD; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Nagao T; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Pezzini A; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Caso V; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Nederkoorn PJ; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Kägi G; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • von Hessling A; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Padjen V; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Cordonnier C; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Erdur H; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Lyrer PA; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Brouns R; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Steiner T; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Tatlisumak T; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
  • Engelter ST; From Stroke Center and Neurology, University Hospital Basel, Switzerland (D.J.S., H.G., C.T., L.H., G.M.D.M., L.H.B., N.P., P.A.L., S.T.E.); Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium (R.-J.V.H., R.B.); Depar
Circulation ; 132(13): 1261-9, 2015 Sep 29.
Article en En | MEDLINE | ID: mdl-26232277
BACKGROUND: We explored the safety of intravenous thrombolysis (IVT) or intra-arterial treatment (IAT) in patients with ischemic stroke on non-vitamin K antagonist oral anticoagulants (NOACs, last intake <48 hours) in comparison with patients (1) taking vitamin K antagonists (VKAs) or (2) without previous anticoagulation (no-OAC). METHODS AND RESULTS: This is a multicenter cohort pilot study. Primary outcome measures were (1) occurrence of intracranial hemorrhage (ICH) in 3 categories: any ICH (ICHany), symptomatic ICH according to the criteria of the European Cooperative Acute Stroke Study II (ECASS-II) (sICHECASS-II) and the National Institute of Neurological Disorders and Stroke (NINDS) thrombolysis trial (sICHNINDS); and (2) death (at 3 months). Cohorts were compared by using propensity score matching. Our NOAC cohort comprised 78 patients treated with IVT/IAT and the comparison groups of 441 VKA patients and 8938 no-OAC patients. The median time from last NOAC intake to IVT/IAT was 13 hours (interquartile range, 8-22 hours). In VKA patients, median pre-IVT/IAT international normalized ratio was 1.3 (interquartile range, 1.1-1.6). ICHany was observed in 18.4% NOAC patients versus 26.8% in VKA patients and 17.4% in no-OAC patients. sICHECASS-II and sICHNINDS occurred in 2.6%/3.9% NOAC patients, in comparison with 6.5%/9.3% of VKA patients and 5.0%/7.2% of no-OAC patients, respectively. At 3 months, 23.0% of NOAC patients in comparison with 26.9% of VKA patients and 13.9% of no-OAC patients had died. Propensity score matching revealed no statistically significant differences. CONCLUSIONS: IVT/IAT in selected patients with ischemic stroke under NOAC treatment has a safety profile similar to both IVT/IAT in patients on subtherapeutic VKA treatment or in those without previous anticoagulation. However, further prospective studies are needed, including the impact of specific coagulation tests.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Terapia Trombolítica / Hemorragia Cerebral / Isquemia Encefálica / Antitrombinas / Fibrinolíticos / Inhibidores del Factor Xa / Anticoagulantes Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Terapia Trombolítica / Hemorragia Cerebral / Isquemia Encefálica / Antitrombinas / Fibrinolíticos / Inhibidores del Factor Xa / Anticoagulantes Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article