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Molecular dynamics and density functional studies on the metabolic selectivity of antipsychotic thioridazine by cytochrome P450 2D6: Connection with crystallographic and metabolic results.
Sasahara, Katsunori; Mashima, Akira; Yoshida, Tatsusada; Chuman, Hiroshi.
  • Sasahara K; Institute of Biomedical Sciences, Tokushima University Graduate School, 1-78 Shomachi, Tokushima 770-8505, Japan; Department of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
  • Mashima A; Institute of Biomedical Sciences, Tokushima University Graduate School, 1-78 Shomachi, Tokushima 770-8505, Japan.
  • Yoshida T; Institute of Biomedical Sciences, Tokushima University Graduate School, 1-78 Shomachi, Tokushima 770-8505, Japan.
  • Chuman H; Institute of Biomedical Sciences, Tokushima University Graduate School, 1-78 Shomachi, Tokushima 770-8505, Japan. Electronic address: hchuman@tokushima-u.ac.jp.
Bioorg Med Chem ; 23(17): 5459-65, 2015 Sep 01.
Article en En | MEDLINE | ID: mdl-26264841
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tioridazina / Antipsicóticos Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tioridazina / Antipsicóticos Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article