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Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Kostov, Rumen V; Knatko, Elena V; McLaughlin, Lesley A; Henderson, Colin J; Zheng, Suqing; Huang, Jeffrey T-J; Honda, Tadashi; Dinkova-Kostova, Albena T.
  • Kostov RV; Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
  • Knatko EV; Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
  • McLaughlin LA; Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
  • Henderson CJ; Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
  • Zheng S; Department of Chemistry and Institute of Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Huang JT; Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
  • Honda T; Department of Chemistry and Institute of Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Dinkova-Kostova AT; Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, DD1 9SY, Scotland, UK; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins Un
Biochem Biophys Res Commun ; 465(3): 402-7, 2015 Sep 25.
Article en En | MEDLINE | ID: mdl-26265043
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenantrenos / Factor 2 Relacionado con NF-E2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenantrenos / Factor 2 Relacionado con NF-E2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article