Fibroblastic connective tissue nevus.
J Cutan Pathol
; 43(1): 75-9, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26268513
ABSTRACT
Fibroblastic connective tissue nevus (FCTN) is a newly recognized, benign cutaneous mesenchymal lesion of fibroblasts/myofibroblastic lineage, which expands the classification of connective tissue nevi. We present three cases of FCTN and discuss significant clinical, morphologic and immunophenotypic overlap with dermatomyofibroma. Our cases were from young women, aged 32, 24 and 10, and presented as 1.2 and 1 cm nodules on the posterior neck and right upper flank, respectively while presenting as a linear plaque of the right posterior thigh in the latter case. The lesions showed a poorly circumscribed proliferation of hypercellular spindle cells arranged in short to longer intersecting fascicles entrapping adnexal structures. Superficial adipose tissue was also entrapped in one case. The spindle cells had fibroblastic features with pale eosinophilic cytoplasmic extensions and inconspicuous nucleoli. The spindle cells were positive for CD34 in two cases. One case was negative for CD34, smooth muscle actin (SMA), desmin and S100. The overall features were consistent with a diagnosis of FCTN. In two cases, we further elucidated the fibroblastic differentiation of the spindle cells in FCTN with electron microscopy, which has not been previously described.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fibroblastos
/
Nevo
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Child
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Female
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article