Use of the 2-chlorotrityl chloride resin for microwave-assisted solid phase peptide synthesis.
Biopolymers
; 104(5): 506-14, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-26270247
ABSTRACT
A fast and efficient microwave (MW)-assisted solid-phase peptide synthesis protocol using the 2-chlorotrityl chloride resin and the Fmoc/tBu methodology, has been developed. The established protocol combines the advantages of MW irradiation and the acid labile 2-chlorotrityl chloride resin. The effect of temperature during the MW irradiation, the degree of resin substitution during the coupling of the first amino acids and the rate of racemization for each amino acid were evaluated. The suggested solid phase methodology is applicable for orthogonal peptide synthesis and for the synthesis of cyclic peptides.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
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Compuestos de Tritilo
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Técnicas de Química Analítica
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Técnicas de Síntesis en Fase Sólida
Idioma:
En
Año:
2015
Tipo del documento:
Article