Association between long-term exposure to air pollution and mortality in France: A 25-year follow-up study.
Environ Int
; 85: 5-14, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26298834
ABSTRACT
INTRODUCTION:
Long-term exposure to air pollution (AP) has been shown to have an impact on mortality in numerous countries, but since 2005 no data exists for France.OBJECTIVES:
We analyzed the association between long-term exposure to air pollution and mortality at the individual level in a large French cohort followed from 1989 to 2013.METHODS:
The study sample consisted of 20,327 adults working at the French national electricity and gas company EDF-GDF. Annual exposure to PM10, PM102.5, PM2.5, NO2, O3, SO2, and benzene was assessed for the place of residence of participants using a chemistry-transport model and taking residential history into account. Hazard ratios were estimated using a Cox proportional-hazards regression model, adjusted for selected individual and contextual risk factors. Hazard ratios were computed for an interquartile range (IQR) increase in air pollutant concentrations.RESULTS:
The cohort recorded 1967 non-accidental deaths. Long-term exposures to b aseline PM2.5, PM10-25, NO2 and benzene were associated with an increase in non-accidental mortality (Hazard Ratio, HR = 1.09; 95% CI 0.99, 1.20 per 5.9 µg/m3, PM10-25; HR=1.09; 95% CI 1.04, 1.15 per 2.2 µg/m3, NO2 HR=1.14; 95% CI 0.99, 1.31 per 19.3 µg/m3 and benzene HR=1.10; 95% CI 1.00, 1.22 per 1.7 µg/m3).The strongest association was found for PM10 HR = 1.14; 95% CI 1.05, 1.25 per 7.8 µg/m3. PM10, PM10-25 and SO2 were associated with non-accidental mortality when using time varying exposure. No significant associations were observed between air pollution and cardiovascular and respiratory mortality.CONCLUSION:
Long-term exposure to fine particles, nitrogen dioxide, sulfur dioxide and benzene is associated with an increased risk of non-accidental mortality in France. Our results strengthen existing evidence that outdoor air pollution is a significant environmental risk factor for mortality. Due to the limited sample size and the nature of our study (occupational), further investigations are needed in France with a larger representative population sample.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Respiratorias
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Enfermedades Cardiovasculares
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Contaminantes Atmosféricos
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Exposición a Riesgos Ambientales
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Material Particulado
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2015
Tipo del documento:
Article