Discovery of novel lysine É-aminotransferase inhibitors: An intriguing potential target for latent tuberculosis.

Devi, Parthiban Brindha; Sridevi, Jonnalagadda Padma; Kakan, Shruti Singh; Saxena, Shalini; Jeankumar, Variam Ullas; Soni, Vijay; Anantaraju, Hasitha Shilpa; Yogeeswari, Perumal; Sriram, Dharmarajan

Discovery of novel lysine É-aminotransferase inhibitors: An intriguing potential target for latent tuberculosis.

Devi, Parthiban Brindha; Sridevi, Jonnalagadda Padma; Kakan, Shruti Singh; Saxena, Shalini; Jeankumar, Variam Ullas; Soni, Vijay; Anantaraju, Hasitha Shilpa; Yogeeswari, Perumal; Sriram, Dharmarajan.

Devi PB; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Sridevi JP; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Kakan SS; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Saxena S; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Jeankumar VU; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Soni V; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Anantaraju HS; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Yogeeswari P; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India.
Sriram D; Centre for Infectious Disease Research, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Hyderabad 500078, India. Electronic address: dsriram@hyderabad.bits-pilani.ac.in.

Tuberculosis (Edinb) ; 95(6): 786-794, 2015 Dec.

Article en En | MEDLINE | ID: mdl-26299907

Asunto(s)

Antituberculosos/farmacología; Proteínas Bacterianas/antagonistas & inhibidores; Descubrimiento de Drogas/métodos; Inhibidores Enzimáticos/farmacología; L-Lisina 6-Transaminasa/antagonistas & inhibidores; Tuberculosis Latente/tratamiento farmacológico; Mycobacterium tuberculosis/efectos de los fármacos; Animales; Antituberculosos/síntesis química; Proteínas Bacterianas/metabolismo; Modelos Animales de Enfermedad; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/síntesis química; Humanos; L-Lisina 6-Transaminasa/metabolismo; Tuberculosis Latente/diagnóstico; Tuberculosis Latente/microbiología; Viabilidad Microbiana/efectos de los fármacos; Simulación del Acoplamiento Molecular; Estructura Molecular; Terapia Molecular Dirigida; Infecciones por Mycobacterium no Tuberculosas/tratamiento farmacológico; Infecciones por Mycobacterium no Tuberculosas/microbiología; Mycobacterium marinum/efectos de los fármacos; Mycobacterium marinum/enzimología; Mycobacterium tuberculosis/enzimología; Mycobacterium tuberculosis/crecimiento & desarrollo; Relación Estructura-Actividad; Factores de Tiempo; Pez Cebra

Palabras clave

Latent tuberculosis; Lysine É-aminotransferase; Mycobacterium tuberculosis; Zebra fish M. marinum model

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Inhibidores Enzimáticos / L-Lisina 6-Transaminasa / Descubrimiento de Drogas / Tuberculosis Latente / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article

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