Magnetic NGF-releasing PLLA/iron oxide nanoparticles direct extending neurites and preferentially guide neurites along aligned electrospun microfibers.
ACS Chem Neurosci
; 6(11): 1781-8, 2015 Nov 18.
Article
en En
| MEDLINE
| ID: mdl-26322376
ABSTRACT
Nerve growth factor releasing composite nanoparticles (NGF-cNPs) were developed to direct the extension of neurite outgrowth from dorsal root ganglia (DRG). Iron oxide magnetic nanoparticles were incorporated into poly-l-lactic acid (PLLA) nanoparticles in order to position the NGF-cNPs in a culture dish. Neurites growing from DRG extended toward the NGF released from the NGF-cNPs. DRG were then cultured on aligned PLLA microfibers in the presence of NGF-cNPs, and these biomaterials combined to align DRG neurite extension along one axis and preferentially toward the NGF-cNPs. This combinatorial biomaterial approach shows promise as a strategy to direct the extension of regenerating neurites.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neuritas
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Sistemas de Liberación de Medicamentos
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Fármacos Neuroprotectores
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Factor de Crecimiento Nervioso
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Nanopartículas de Magnetita
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article