Continued Slow Decay of the Residual Plasma Viremia Level in HIV-1-Infected Adults Receiving Long-term Antiretroviral Therapy.
J Infect Dis
; 213(4): 556-60, 2016 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-26333941
ABSTRACT
UNLABELLED We measured plasma human immunodeficiency virus type 1 (HIV-1) RNA levels by means of single-copy assay in 334 participants receiving virologically suppressive antiretroviral therapy (ART). A residual viremia load of ≥1 copy/mL after 4 years of ART was predicted by a higher pre-ART HIV-1 RNA level, higher CD8(+) T-cell count during treatment, and a lower ratio of CD4+ T cells to CD8+ T cells during treatment but not by initial ART regimen. In a longitudinal subset of 64 individuals, continued decay of the plasma HIV-1 RNA level was observed, with an average annual decrease of 6% and an estimated half-life of 11.5 years. In contrast to prior reports, the persistent viremia level continues to slowly decline during years 4-12 of suppressive ART. CLINICAL TRIALS REGISTRATION NCT00001137.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasma
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Infecciones por VIH
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VIH-1
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Carga Viral
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Terapia Antirretroviral Altamente Activa
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Antirretrovirales
Tipo de estudio:
Clinical_trials
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2016
Tipo del documento:
Article