Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats.
J Neuroinflammation
; 12: 162, 2015 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-26337974
ABSTRACT
BACKGROUND:
Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.OBJECTIVE:
The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.METHODS:
Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.RESULTS:
In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).CONCLUSIONS:
DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estado Epiléptico
/
Apoptosis
/
Estimulación Encefálica Profunda
/
Encefalitis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article