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Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats.
Amorim, Beatriz O; Covolan, Luciene; Ferreira, Elenn; Brito, José Geraldo; Nunes, Diego P; de Morais, David G; Nobrega, José N; Rodrigues, Antonio M; deAlmeida, Antonio Carlos G; Hamani, Clement.
  • Amorim BO; Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, 04023-062, São Paulo, Brazil. beatriz.oamorim@gmail.com.
  • Covolan L; Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, 04023-062, São Paulo, Brazil. lucovolan@gmail.com.
  • Ferreira E; Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, 04023-062, São Paulo, Brazil. elenn_ferreira@msn.com.
  • Brito JG; Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, 04023-062, São Paulo, Brazil. jgabrito@gmail.com.
  • Nunes DP; Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, 04023-062, São Paulo, Brazil. diegopannunzio@hotmail.com.
  • de Morais DG; Disciplina de Neurofisiologia, Universidade Federal de São Paulo, Rua Botucatu, 862 5 andar, 04023-062, São Paulo, Brazil. baratchowisky@bol.com.br.
  • Nobrega JN; Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada. j.nobrega@utoronto.ca.
  • Rodrigues AM; Departamento de Engenharia de Biossistemas, Universidade Federal de São João del-Rei, São João del-Rei, MG, 36301-160, Brazil. amr@ufsj.edu.br.
  • deAlmeida AC; Departamento de Engenharia de Biossistemas, Universidade Federal de São João del-Rei, São João del-Rei, MG, 36301-160, Brazil. acga@ufsj.edu.br.
  • Hamani C; Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada. c.hamani@sympatico.ca.
J Neuroinflammation ; 12: 162, 2015 Sep 04.
Article en En | MEDLINE | ID: mdl-26337974
ABSTRACT

BACKGROUND:

Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.

OBJECTIVE:

The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.

METHODS:

Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.

RESULTS:

In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).

CONCLUSIONS:

DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estado Epiléptico / Apoptosis / Estimulación Encefálica Profunda / Encefalitis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estado Epiléptico / Apoptosis / Estimulación Encefálica Profunda / Encefalitis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article