Evaluation of the "Dip Effect" Phenomenon in Antifungal Susceptibility Testing of Candida spp. against Echinocandins by Use of Gradient Concentration Strips.
J Clin Microbiol
; 53(11): 3654-9, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26338855
ABSTRACT
The "dip effect" phenomenon complicates antifungal susceptibility testing with gradient concentration strips. Of 60 Candida isolates tested with the three echinocandins, this phenomenon was observed only for caspofungin with most (>90%) Candida albicans, Candida glabrata, and Candida tropicalis isolates and for isolates with CLSI MICs of ≤0.25 mg/liter. In order to facilitate MIC determination, a practical approach was developed using the inhibition zones at 32, 8, 2, and 1 mg/liter, increasing the agreement with the CLSI method >86%.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Candida albicans
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Candida glabrata
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Candida tropicalis
/
Equinocandinas
/
Antifúngicos
Límite:
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article