SUMO-regulated transcription: challenging the dogma.
Bioessays
; 37(10): 1095-105, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26354225
ABSTRACT
The small ubiquitin-like modifier SUMO regulates many aspects of cellular physiology to maintain cell homeostasis, both under normal conditions and during cell stress. Components of the transcriptional apparatus and chromatin are among the most prominent SUMO substrates. The prevailing view is that SUMO serves to repress transcription. However, as we will discuss in this review, this model needs to be refined, because recent studies have revealed that SUMO can also have profound positive effects on transcription.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
Regulación de la Expresión Génica
/
Proteína SUMO-1
Límite:
Animals
/
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article