A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4.

Templeton, Ian; Ravenstijn, Paulien; Sensenhauser, Carlo; Snoeys, Jan

Templeton, Ian; Ravenstijn, Paulien; Sensenhauser, Carlo; Snoeys, Jan.

Templeton I; Janssen Research & Development, LLC, Raritan, NJ, USA.
Ravenstijn P; Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
Sensenhauser C; Janssen Research & Development, LLC, Raritan, NJ, USA.
Snoeys J; Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.

Biopharm Drug Dispos ; 37(1): 15-27, 2016 Jan.

Article en En | MEDLINE | ID: mdl-26356245

Asunto(s)

Inhibidores del Citocromo P-450 CYP3A/farmacología; Domperidona/farmacocinética; Antagonistas de Dopamina/farmacocinética; Modelos Biológicos; Adolescente; Adulto; Células CACO-2; Simulación por Computador; Interacciones Farmacológicas; Eritromicina/farmacología; Femenino; Humanos; Itraconazol/farmacología; Cetoconazol/farmacología; Masculino; Microsomas Hepáticos/metabolismo; Persona de Mediana Edad; Adulto Joven

Palabras clave

CYP3A4; domperidone; drug-drug interactions; pharmacokinetic modeling

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antagonistas de Dopamina / Domperidona / Inhibidores del Citocromo P-450 CYP3A / Modelos Biológicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article

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