Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Matarlo, Joe S; Evans, Christopher E; Sharma, Indrajeet; Lavaud, Lubens J; Ngo, Stephen C; Shek, Roger; Rajashankar, Kanagalaghatta R; French, Jarrod B; Tan, Derek S; Tonge, Peter J

Matarlo, Joe S; Evans, Christopher E; Sharma, Indrajeet; Lavaud, Lubens J; Ngo, Stephen C; Shek, Roger; Rajashankar, Kanagalaghatta R; French, Jarrod B; Tan, Derek S; Tonge, Peter J.

Matarlo JS; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400.
Evans CE; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-3400.
Sharma I; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Lavaud LJ; Chemical Biology Program and Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Ngo SC; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400.
Shek R; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400.
Rajashankar KR; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-3400.
French JB; NE-CAT and Department of Chemistry and Chemical Biology, Building 436E, Argonne National Laboratory, Argonne, IL 60439.
Tan DS; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400.
Tonge PJ; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400.

Biochemistry ; 54(42): 6514-6524, 2015 10 27.

Article en En | MEDLINE | ID: mdl-26394156

Asunto(s)

Antibacterianos/química; Antibacterianos/farmacología; Proteínas de Escherichia coli/antagonistas & inhibidores; Proteínas de Escherichia coli/química; Succinato-CoA Ligasas/antagonistas & inhibidores; Succinato-CoA Ligasas/química; Secuencia de Aminoácidos; Animales; Antibacterianos/toxicidad; Arginina/química; Dominio Catalítico/genética; Chlorocebus aethiops; Secuencia Conservada; Cristalografía por Rayos X; Descubrimiento de Drogas; Escherichia coli K12/enzimología; Escherichia coli K12/genética; Proteínas de Escherichia coli/genética; Pruebas de Sensibilidad Microbiana; Modelos Moleculares; Datos de Secuencia Molecular; Mutagénesis Sitio-Dirigida; Fenilbutiratos/química; Fenilbutiratos/farmacología; Fenilbutiratos/toxicidad; Conformación Proteica; Homología de Secuencia de Aminoácido; Staphylococcus aureus/efectos de los fármacos; Staphylococcus aureus/metabolismo; Relación Estructura-Actividad; Succinato-CoA Ligasas/genética; Células Vero; Vitamina K 2/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Succinato-CoA Ligasas / Proteínas de Escherichia coli / Antibacterianos Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article

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