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Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation.
Choi, Boyoon; Kim, Myeong Gyu; Han, Nayoung; Kim, Therasa; Ji, Eunhee; Park, Seonyang; Kim, In-Wha; Oh, Jung Mi.
  • Choi B; College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
  • Kim MG; College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
  • Han N; College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
  • Kim T; College of Pharmacy, Chonnam National University, Gwangju, Korea.
  • Ji E; College of Pharmacy, Gachon University, Incheon, Korea.
  • Park S; Department of Internal Medicine, Seoul National University Medicine of College, Seoul, Korea.
  • Kim IW; College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
  • Oh JM; College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
Pharmacogenomics ; 16(14): 1585-94, 2015.
Article en En | MEDLINE | ID: mdl-26419450
AIM: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. PATIENTS & METHODS: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. RESULTS: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients. CONCLUSION: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Busulfano / Trasplante de Células Madre Hematopoyéticas / Glutatión Transferasa / Inmunosupresores Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Busulfano / Trasplante de Células Madre Hematopoyéticas / Glutatión Transferasa / Inmunosupresores Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article