Cost-effectiveness and budget impact of Empirical vitamin D therapy on unintentional falls in older adults in the UK.
BMJ Open
; 5(9): e007910, 2015 Sep 29.
Article
en En
| MEDLINE
| ID: mdl-26419680
ABSTRACT
OBJECTIVES:
To evaluate the health outcomes and economics associated with the current guidance relating to the prevention of falls in the elderly through vitamin D supplementation.SETTING:
UK.PARTICIPANTS:
UK population aged 60â years and above.INTERVENTIONS:
A Markov health state transition model simulated patient transitions between key fall-related outcomes using a 5-year horizon and annual cycles to assess the costs and benefits of empirical treatment with colecalciferol 800â iu daily. PRIMARY AND SECONDARY OUTCOMEMEASURES:
Costs and health outcomes attributable to fall prevention following vitamin D supplementation.RESULTS:
Our model shows that treating the UK population aged 60â years and above with 800â iu colecalciferol would, over a 5-year period (1) prevent in excess of 430,000 minor falls; (2) avoid 190,000 major falls; (3) prevent 1579 acute deaths; (4) avoid 84,000 person-years of long-term care and (5) prevent 8300 deaths associated with increased mortality in long-term care. The greatest gains are seen among those 75â years and older. Based on reduction in falls alone, the intervention in all adults aged 65+ is cost-saving and leads to increased quality adjusted life years. Treating all adults aged 60+ incurs an intervention cost of £2.70bn over 5â years, yet produces a -£3.12bn reduction in fall-related costs; a net saving of £420M. Increasing the lower bound age limit by 5-year increments increases budget impact to -£1.17bn, -£1.75bn, and -£2.06bn for adults 65+, 70+ and 75+, respectively.CONCLUSIONS:
This study shows that treatment of the elderly UK population with colecalciferol 800â iu daily would be associated with reductions in mortality and substantial cost-savings through fall prevention.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Accidentes por Caídas
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Costos de la Atención en Salud
/
Años de Vida Ajustados por Calidad de Vida
Tipo de estudio:
Guideline
/
Health_economic_evaluation
/
Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2015
Tipo del documento:
Article