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Mucin-drugs interaction: The case of theophylline, prednisolone and cephalexin.
Pontremoli, Carlotta; Barbero, Nadia; Viscardi, Guido; Visentin, Sonja.
  • Pontremoli C; Molecular Biotechnology and Health Sciences Department, University of Torino, via Quarello 15, 10135 Torino, Italy.
  • Barbero N; Department of Chemistry and NIS Interdepartmental Centre, University of Torino, via Pietro Giuria 7, 10125 Torino, Italy.
  • Viscardi G; Department of Chemistry and NIS Interdepartmental Centre, University of Torino, via Pietro Giuria 7, 10125 Torino, Italy.
  • Visentin S; Molecular Biotechnology and Health Sciences Department, University of Torino, via Quarello 15, 10135 Torino, Italy. Electronic address: sonja.visentin@unito.it.
Bioorg Med Chem ; 23(20): 6581-6, 2015 Oct 15.
Article en En | MEDLINE | ID: mdl-26422788
ABSTRACT
The binding of mucin with three commercially available drugs (theophylline, cephalexin and prednisolone) belonging to different pharmaceutical classes was investigated. The studied drugs are normally used to treat the symptomatology of cystic fibrosis. The interaction between drugs and mucin has been investigated using fluorescence and UV-Vis absorption spectroscopy; quenching mechanism, binding constants, binding sites, thermodynamic parameters and binding distance of the interaction were obtained.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Teofilina / Prednisolona / Cefalexina / Mucinas Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Teofilina / Prednisolona / Cefalexina / Mucinas Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article