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Raltegravir Pharmacokinetics in Patients on Asunaprevir-Daclatasvir.
Barrail-Tran, Aurélie; Vincent, Corine; Furlan, Valérie; Rosa, Isabelle; Rosenthal, Eric; Cheret, Antoine; Molina, Jean-Michel; Taburet, Anne-Marie; Piroth, Lionel.
  • Barrail-Tran A; AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France Université Paris Sud, INSERM UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, France aurelie.barrail-tran@bct.aphp.fr.
  • Vincent C; INSERM SC10-US019, Villejuif, France.
  • Furlan V; AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France.
  • Rosa I; Centre Hospitalier Intercommunal, Service d'Hépato-Gastro-Entérologie, Créteil, France.
  • Rosenthal E; CHU de Nice, Hôpital de l'Archet, Service de Médecine Interne, Nice, France.
  • Cheret A; CH de Tourcoing Hôpital Gustave Dron, SRU Maladies Infectieuses et du Voyageur, Tourcoing, France.
  • Molina JM; Hôpital Saint Louis Université Paris Diderot, Service des Maladies Infectieuses et Tropicales, Paris, France.
  • Taburet AM; AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France Université Paris Sud, INSERM UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, France.
  • Piroth L; Infectious Diseases Department, Centre Hospitalo-Universitaire, and UMR 1347, Université de Bourgogne, Dijon, France.
Antimicrob Agents Chemother ; 59(12): 7903-5, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26438504
ABSTRACT
Raltegravir pharmacokinetics was studied in 20 patients included in the ANRS HC30 QUADRIH Study before and after addition of anti-hepatitis C virus (anti-HCV) quadritherapy, including pegylated-interferon-ribavirin and asunaprevir plus daclatasvir. Raltegravir pharmacokinetic parameters remained unchanged whether administered on or off anti-HCV therapy. In addition, concentrations of raltegravir, asunaprevir, and daclatasvir were not affected by liver cirrhosis. These data suggest that in human immunodeficiency virus (HIV)-HCV-coinfected patients, whether cirrhotic or not, asunaprevir and daclatasvir could be administered safely with raltegravir.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Sulfonamidas / Infecciones por VIH / Hepatitis C Crónica / Raltegravir Potásico / Imidazoles / Isoquinolinas Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Sulfonamidas / Infecciones por VIH / Hepatitis C Crónica / Raltegravir Potásico / Imidazoles / Isoquinolinas Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article