The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients.
PLoS One
; 10(10): e0140062, 2015.
Article
en En
| MEDLINE
| ID: mdl-26445018
ABSTRACT
BACKGROUND:
Stunting, anemia and inflammation are frequently observed in children with end-stage renal disease (ESRD).OBJECTIVES:
To assess anthropometric, hematological and inflammatory data and to study their potential interrelationship in Guatemalan juveniles undergoing hemodialysis (HD) and peritoneal dialysis (PD).METHODS:
54 juveniles 7-20 years of age were recruited in FUNDANIER, Guatemala City 27 on HD and 27 PD. Hemoglobin, serum iron, transferrin, serum transferrin receptor (sTfR), serum ferritin, transferrin saturation and iron-binding capacity, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), as well as IL-6, IL-1 and TNF-α, weight and height were determined by standard methods. Hepcidin-25 (Hep-25) was assessed by weak cation exchange time-of-flight mass-spectrometry.RESULTS:
92% and 55% of HD and PD children, respectively, were stunted and 95% and 85% were anemic. Among iron status biomarkers, serum ferritin was massively increased and significantly higher in the HD group compared to the PD group. Hep-25 was also greatly elevated in both groups. 41% of HD patients showed increments in three or more inflammatory biomarkers, while it was 2 or less in all PD subjects.CONCLUSIONS:
The degree of stunting, the prevalence and severity of anemia in Guatemalan juvenile ESRD far exceed the national statistics for this low-income Central American country. Ferritin and Hep-25 concentrations were elevated, with the latter to an extraordinary magnitude. Additional biomarkers of inflammation not directly related to iron status were elevated as well. The role of both disease- and environment-related factors in combination best explains the magnitude of the biomarker abnormalities.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inflamación
/
Anemia
/
Fallo Renal Crónico
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
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Female
/
Humans
/
Male
País como asunto:
America central
/
Guatemala
Idioma:
En
Año:
2015
Tipo del documento:
Article