Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in a Patient with Chronic Granulomatous Disease and Active Infection: A First Report.
J Clin Immunol
; 35(7): 675-80, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26453586
ABSTRACT
PURPOSE:
We describe haploidentical hematopoietic cell transplantation (HCT) with high-dose post-transplant cyclophosphamide (PTCy) in a boy with x-linked chronic granulomatous disease (CGD).METHODS:
A persistent and life-threatening fungal infection was the indication for HSCT. Non-myeloablative conditioning with PTCy (50 mg/kg days 3 and 4) was used in the absence of fully matched donors.RESULTS:
Engraftment occurred on day 24. The patient experienced Grade 2 graft-versus-host disease of the skin and gastrointestinal tract and CMV infection, both of which were controlled. Chimerism was 100 % at days 30 and 6 months. Cessation of antifungal therapy was consistent with cure of the infection.CONCLUSIONS:
Haploidentical HCT with high-dose PTCy for CGD is feasible and succeeded even in the context of active infection.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Transfusión de Sangre Autóloga
/
Scedosporium
/
Ciclofosfamida
/
Enfermedad Injerto contra Huésped
/
Enfermedad Granulomatosa Crónica
/
Inmunosupresores
/
Micosis
Tipo de estudio:
Etiology_studies
Límite:
Humans
/
Infant
/
Male
País como asunto:
America do norte
Idioma:
En
Año:
2015
Tipo del documento:
Article