Inhibitory effects of compounds from Styrax obassia on NO production.
Bioorg Med Chem Lett
; 25(22): 5087-91, 2015 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-26483135
ABSTRACT
Two new benzofurans, 2-(3,4-dimethoxyphenyl)-5-(1,3-dihydroxypropyl)-7-methoxybenzofuran (1) and 2-(3,4-methylenedioxyphenyl)-5-(3-hydroxymethyletoxy-1-hydroxypropyl)-7-methoxybenzofuran (2), a new triterpene, 3ß, 6ß, 21ß-trihydroxyolean-12-ene (3), and eleven known compounds were isolated from the stem bark of Styrax obassia. The structures of the isolated compounds were established by extensive spectroscopic analyses, including 1D and 2D NMR and HRMS. Their anti-inflammatory activities were evaluated against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Compound 1 was shown to reduce LPS-induced iNOS expression in a dose-dependent manner. In addition, pretreating cells with 1 significantly suppressed their LPS-induced expression of COX-2 protein.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Antiinflamatorios no Esteroideos
/
Styrax
/
Óxido Nítrico
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article