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Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses.
Song, Min-Suk; Baek, Yun Hee; Pascua, Philippe Noriel Q; Kwon, Hyeok-Il; Kim, Eun-Ha; Park, Su-Jin; Kim, Se Mi; Kim, Young-Il; Choi, Won-Suk; Kim, Eung-Gook; Kim, Chul-Joong; Choi, Young Ki.
  • Song MS; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Baek YH; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Pascua PN; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kwon HI; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim EH; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Park SJ; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim SM; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim YI; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Choi WS; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim EG; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim CJ; College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
  • Choi YK; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea choiki55@chungbuk.ac.kr.
J Virol ; 90(1): 616-23, 2016 01 01.
Article en En | MEDLINE | ID: mdl-26491154
ABSTRACT
Coinfection of ferrets with H5N1 and pH1N1 viruses resulted in two predominate genotypes in the lungs containing surface genes of highly pathogenic avian influenza H5N1 virus in the backbone of pandemic H1N1 2009 (pH1N1). Compared to parental strains, these reassortants exhibited increased growth and virulence in vitro and in mice but failed to be transmitted indirectly to naive contact ferrets. Thus, this demonstrates a possible natural reassortment following coinfection as well as the pathogenicity of the potential reassortants.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Virus Reordenados / Infecciones por Orthomyxoviridae / Subtipo H1N1 del Virus de la Influenza A / Subtipo H5N1 del Virus de la Influenza A / Coinfección Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Virus Reordenados / Infecciones por Orthomyxoviridae / Subtipo H1N1 del Virus de la Influenza A / Subtipo H5N1 del Virus de la Influenza A / Coinfección Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article