Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent.

Cao, Jia; Adler, Ben; Perlmutter, Patrick

Cao, Jia; Adler, Ben; Perlmutter, Patrick.

Cao J; School of Chemistry, Monash University, Clayton, VIC 3800, Australia.
Adler B; Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
Perlmutter P; School of Chemistry, Monash University, Clayton, VIC 3800, Australia.

Bioorg Med Chem Lett ; 25(22): 5025-7, 2015 Nov 15.

Article en En | MEDLINE | ID: mdl-26497285

ABSTRACT

ABSTRACT

A putative antibacterial and antifungal compound, (R)-2-methylheptyl isonicotinate, was synthesized via reductive lactone alkylation of (R)-4-methyldihydrofuran-2(3H)-one. Structural characterisation data as well as bioassay results (with Bacillus subtilis or Escherichia coli) contradict those previously reported.

Asunto(s)

Antibacterianos/síntesis química; Antibacterianos/farmacología; Ácidos Isonicotínicos/síntesis química; Ácidos Isonicotínicos/farmacología; Ampicilina/farmacología; Antibacterianos/química; Bacillus subtilis/efectos de los fármacos; Escherichia coli/efectos de los fármacos; Ácidos Isonicotínicos/química; Estructura Molecular

Palabras clave

Antibacterial; Isonicotinate; Natural product; Total synthesis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Isonicotínicos / Antibacterianos Idioma: En Año: 2015 Tipo del documento: Article

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Isonicotínicos / Antibacterianos Idioma: En Año: 2015 Tipo del documento: Article