Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones.
Chemistry
; 21(50): 18033-7, 2015 Dec 07.
Article
en En
| MEDLINE
| ID: mdl-26503672
ABSTRACT
An improved domino hydroformylation/benzoin condensation to give α-hydroxy ketones has been developed. Easily available olefins are smoothly converted into the corresponding α-hydroxy ketones in high yields with excellent regioselectivities. Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene.
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MEDLINE
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2015
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Article