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The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.
Turner, Mark J; Matthes, Elizabeth; Billet, Arnaud; Ferguson, Amy J; Thomas, David Y; Randell, Scott H; Ostrowski, Lawrence E; Abbott-Banner, Kathy; Hanrahan, John W.
  • Turner MJ; Department of Physiology, McIntyre Medical Sciences Building, McGill University, Montreal, Canada; McGill CF Translational Research Centre, Montreal, Canada; mark.turner2@mail.mcgill.ca.
  • Matthes E; Department of Physiology, McIntyre Medical Sciences Building, McGill University, Montreal, Canada; McGill CF Translational Research Centre, Montreal, Canada;
  • Billet A; Department of Physiology, McIntyre Medical Sciences Building, McGill University, Montreal, Canada; McGill CF Translational Research Centre, Montreal, Canada;
  • Ferguson AJ; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina;
  • Thomas DY; McGill CF Translational Research Centre, Montreal, Canada; Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Canada;
  • Randell SH; Department of Cell Biology and Physiology and the Marsico Lung Institute/Cystic Fibrosis Center, University of North Carolina, Chapel Hill, North Carolina;
  • Ostrowski LE; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina;
  • Abbott-Banner K; Verona Pharma plc, London, United Kingdom; and.
  • Hanrahan JW; Department of Physiology, McIntyre Medical Sciences Building, McGill University, Montreal, Canada; McGill CF Translational Research Centre, Montreal, Canada; Research Institute of the McGill University Health Centre, Montreal, Canada.
Am J Physiol Lung Cell Mol Physiol ; 310(1): L59-70, 2016 Jan 01.
Article en En | MEDLINE | ID: mdl-26545902
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinonas / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Células Epiteliales / Inhibidores de Fosfodiesterasa 3 / Inhibidores de Fosfodiesterasa 4 / Isoquinolinas Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinonas / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Células Epiteliales / Inhibidores de Fosfodiesterasa 3 / Inhibidores de Fosfodiesterasa 4 / Isoquinolinas Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article