Update on Mastocytosis (Part 1): Pathophysiology, Clinical Features, and Diagnosis.
Actas Dermosifiliogr
; 107(1): 5-14, 2016.
Article
en En, Es
| MEDLINE
| ID: mdl-26546030
ABSTRACT
Mastocytosis is a term used to describe a heterogeneous group of disorders characterized by clonal proliferation of mast cells in various organs. The organ most often affected is the skin. Mastocytosis is a relatively rare disorder that affects both sexes equally. It can occur at any age, although it tends to appear in the first decade of life, or later, between the second and fifth decades. Our understanding of the pathophysiology of mastocytosis has improved greatly in recent years, with the discovery that somatic c-kit mutations and aberrant immunophenotypic features have an important role. The clinical manifestations of mastocytosis are diverse, and skin lesions are the key to diagnosis in most patients.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Mastocitosis
/
Mastocitos
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
/
Es
Año:
2016
Tipo del documento:
Article