Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.
Biochem Soc Trans
; 43(4): 553-8, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26551692
ABSTRACT
The highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands.
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MEDLINE
Asunto principal:
Esteroides
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Receptores de GABA
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Metabolismo Energético
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Mitocondrias
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Mutación
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article