Carriage of Enterobacteria Producing Extended-Spectrum ß-Lactamases and Composition of the Gut Microbiota in an Amerindian Community.
Antimicrob Agents Chemother
; 60(1): 507-14, 2016 01.
Article
en En
| MEDLINE
| ID: mdl-26552974
ABSTRACT
Epidemiological and individual risk factors for colonization by enterobacteria producing extended-spectrum beta-lactamases (E-ESBL) have been studied extensively, but whether such colonization is associated with significant changes in the composition of the rest of the microbiota is still unknown. To address this issue, we assessed in an isolated Amerindian Guianese community whether intestinal carriage of E-ESBL was associated with specificities in gut microbiota using metagenomic and metatranscriptomic approaches. While the richness of taxa of the active microbiota of carriers was similar to that of noncarriers, the taxa were less homogeneous. In addition, species of four genera, Desulfovibrio, Oscillospira, Parabacteroides, and Coprococcus, were significantly more abundant in the active microbiota of noncarriers than in the active microbiota of carriers, whereas such was the case only for species of Desulfovibrio and Oscillospira in the total microbiota. Differential genera in noncarrier microbiota could either be associated with resistance to colonization or be the consequence of the colonization by E-ESBL.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Beta-Lactamasas
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Indígenas Norteamericanos
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Enterobacteriaceae
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Infecciones por Enterobacteriaceae
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Transcriptoma
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Microbioma Gastrointestinal
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Genes Bacterianos
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como asunto:
America do sul
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Guyana francesa
Idioma:
En
Año:
2016
Tipo del documento:
Article