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A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR.
Suhl, Joshua A; Muddashetty, Ravi S; Anderson, Bart R; Ifrim, Marius F; Visootsak, Jeannie; Bassell, Gary J; Warren, Stephen T.
  • Suhl JA; Department of Human Genetics, Emory University, Atlanta, GA 30322;
  • Muddashetty RS; Department of Cell Biology, Emory University, Atlanta, GA 30322;
  • Anderson BR; Department of Human Genetics, Emory University, Atlanta, GA 30322; Department of Cell Biology, Emory University, Atlanta, GA 30322;
  • Ifrim MF; Department of Cell Biology, Emory University, Atlanta, GA 30322;
  • Visootsak J; Department of Human Genetics, Emory University, Atlanta, GA 30322;
  • Bassell GJ; Department of Cell Biology, Emory University, Atlanta, GA 30322;
  • Warren ST; Department of Human Genetics, Emory University, Atlanta, GA 30322; Department of Biochemistry, Emory University, Atlanta, GA 30322; Department of Pediatrics, Emory University, Atlanta, GA 30322 swarren@emory.edu.
Proc Natl Acad Sci U S A ; 112(47): E6553-61, 2015 Nov 24.
Article en En | MEDLINE | ID: mdl-26554012
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Regiones no Traducidas 3' / Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil / Proteína 1 Similar a ELAV / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2015 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Regiones no Traducidas 3' / Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil / Proteína 1 Similar a ELAV / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2015 Tipo del documento: Article