ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
Oncotarget
; 7(2): 1439-50, 2016 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-26595526
ABSTRACT
Programmed cell death 4 (PDCD4) is a tumour suppressor implicated in cancer development and progression and was recently identified as a repressor of cap-independent translation of specific genes involved in the regulation of apoptosis. We show that the RNA-binding protein HuR binds to the PDCD4 3'UTR to protect it from miR-21-induced silencing. However, following H2O2 treatment, PDCD4 mRNA is degraded via miR-21 binding. Importantly, we identify HuR as a novel substrate of the ERK8 kinase pathway in response to H2O2 treatment. We show that phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Cuello Uterino
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Proteínas de Unión al ARN
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MicroARNs
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Quinasas MAP Reguladas por Señal Extracelular
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Proteínas Reguladoras de la Apoptosis
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Proteína 1 Similar a ELAV
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article