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In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles.
Kaps, Leonard; Nuhn, Lutz; Aslam, Misbah; Brose, Alexander; Foerster, Friedrich; Rosigkeit, Sebastian; Renz, Patricia; Heck, Rosario; Kim, Yong Ook; Lieberwirth, Ingo; Schuppan, Detlef; Zentel, Rudolf.
  • Kaps L; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Nuhn L; Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
  • Aslam M; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
  • Brose A; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Foerster F; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Rosigkeit S; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Renz P; Department of Medicine I (Gastroenterology Hepatology, and Nephrology), University Medical Center of Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Heck R; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Kim YO; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
  • Lieberwirth I; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Schuppan D; Institute of Translational Immunology and Research Center for Immune Therapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55101, Mainz, Germany.
  • Zentel R; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Adv Healthc Mater ; 4(18): 2809-15, 2015 Dec 30.
Article en En | MEDLINE | ID: mdl-26627192
ABSTRACT
Cationic nanohydrogel particles loaded with anti-Col1α1 siRNA suppress collagen synthesis and deposition in fibrotic mice Systemically administered 40 nm sized nanogel particles accumulate in collagen-expressing cells in the liver. Their siRNA payload induces a sequence specific in vivo gene knockdown affording an efficient antifibrotic effect in mice with liver fibrosis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polietilenglicoles / Polietileneimina / Hidrogeles / Silenciador del Gen / ARN Interferente Pequeño / Cirrosis Hepática Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polietilenglicoles / Polietileneimina / Hidrogeles / Silenciador del Gen / ARN Interferente Pequeño / Cirrosis Hepática Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article