His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.

Leroy, Emilie; Defour, Jean-Philippe; Sato, Takeshi; Dass, Sharmila; Gryshkova, Vitalina; Shwe, Myat M; Staerk, Judith; Constantinescu, Stefan N; Smith, Steven O

Leroy, Emilie; Defour, Jean-Philippe; Sato, Takeshi; Dass, Sharmila; Gryshkova, Vitalina; Shwe, Myat M; Staerk, Judith; Constantinescu, Stefan N; Smith, Steven O.

Leroy E; From the Ludwig Institute for Cancer Research, 1200 Brussels, Belgium de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
Defour JP; From the Ludwig Institute for Cancer Research, 1200 Brussels, Belgium de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
Sato T; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Dass S; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5215, and.
Gryshkova V; From the Ludwig Institute for Cancer Research, 1200 Brussels, Belgium de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
Shwe MM; From the Ludwig Institute for Cancer Research, 1200 Brussels, Belgium de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
Staerk J; Stem Cell Group, Nordic European Molecular Biology Laboratory Partnership and Center for Molecular Medicine, 0318 Oslo, Norway.
Constantinescu SN; From the Ludwig Institute for Cancer Research, 1200 Brussels, Belgium de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium, stefan.constantinescu@bru.licr.org.
Smith SO; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5215, and steven.o.smith@stonybrook.edu.

J Biol Chem ; 291(6): 2974-87, 2016 Feb 05.

Article en En | MEDLINE | ID: mdl-26627830

Asunto(s)

Proteínas Proto-Oncogénicas/metabolismo; Receptores de Trombopoyetina/metabolismo; Animales; Asparagina/genética; Asparagina/metabolismo; Línea Celular; Histidina/genética; Histidina/metabolismo; Humanos; Ratones; Mutación Missense; Estructura Secundaria de Proteína; Estructura Terciaria de Proteína; Proteínas Proto-Oncogénicas/genética; Receptores de Trombopoyetina/genética

Palabras clave

Mpl; TpoR; cell biology; cytokine; hematopoiesis; membrane biophysics; receptor structure-function; signal transduction; thrombopoietin receptor; transmembrane domain

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Receptores de Trombopoyetina Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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