Immunosurveillance and immunotherapy of tumors by innate immune cells.
Curr Opin Immunol
; 38: 52-8, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26686774
ABSTRACT
Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular pathways leading to the upregulation of their ligands in tumor cells. We also describe mechanisms underlying the elimination of tumor cells by macrophages and a recently characterized mechanism dedicated to sensing cytosolic DNA that is implicated in antitumor immune responses.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
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Regulación Neoplásica de la Expresión Génica
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Inmunidad Innata
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Macrófagos
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Proteínas de Neoplasias
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article