Ultrafast Assessment of the Presence of a High-Risk Mycobacterium tuberculosis Strain in a Population.
J Clin Microbiol
; 54(3): 779-81, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26719445
ABSTRACT
A persistent 8-year infection by a Beijing Mycobacterium tuberculosis strain from a previous outbreak after importation from West Africa obliged us to investigate secondary cases. We developed a multiplex PCR method based on whole-genome sequencing to target strain-specific single nucleotide polymorphisms (SNPs). In 1 week, we analyzed 868 isolates stored over 6 years. Only 2 cases (immigrants from Guinea Conakry) harbored the strain, which ruled out transmission-despite opportunities-and challenged some of the advantages associated with Beijing strains.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Vigilancia de la Población
/
Técnicas de Tipificación Bacteriana
/
Mycobacterium tuberculosis
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article