5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-&#945;-injured L02 hepatocytes through regulating the PERK-eIF2&#945; signaling pathway.

Jiang, Ze-Qun; Ma, Yan-Xia; Li, Mu-Han; Zhan, Xiu-Qin; Zhang, Xu; Wang, Ming-Yan

5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-α-injured L02 hepatocytes through regulating the PERK-eIF2α signaling pathway.

Jiang, Ze-Qun; Ma, Yan-Xia; Li, Mu-Han; Zhan, Xiu-Qin; Zhang, Xu; Wang, Ming-Yan.

Jiang ZQ; Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing 210023, China.
Ma YX; Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing 210023, China.
Li MH; Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing 210023, China.
Zhan XQ; Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing 210023, China.
Zhang X; Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing 210023, China. Electronic address: zhangxu@njucm.edu.cn.
Wang MY; Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing 210023, China.

Chin J Nat Med ; 13(12): 896-905, 2015 Dec.

Article en En | MEDLINE | ID: mdl-26721708

Asunto(s)

Cornus/química; Estrés del Retículo Endoplásmico/efectos de los fármacos; Factor 2 Eucariótico de Iniciación/metabolismo; Furaldehído/análogos & derivados; Hepatocitos/efectos de los fármacos; Extractos Vegetales/farmacología; Factor de Necrosis Tumoral alfa/metabolismo; eIF-2 Quinasa/metabolismo; Apoptosis/efectos de los fármacos; Factor 2 Eucariótico de Iniciación/genética; Furaldehído/farmacología; Galactosamina/metabolismo; Hepatocitos/citología; Hepatocitos/metabolismo; Humanos; Hígado/citología; Hígado/efectos de los fármacos; Hígado/metabolismo; Sustancias Protectoras/farmacología; Transducción de Señal/efectos de los fármacos; Factor de Necrosis Tumoral alfa/genética; eIF-2 Quinasa/genética

Palabras clave

5-Hydroxymethylfurfural; Apoptosis; GalN/TNF-α; L02 hepatocytes; PERK-eIF2α

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Extractos Vegetales / Factor 2 Eucariótico de Iniciación / Factor de Necrosis Tumoral alfa / EIF-2 Quinasa / Hepatocitos / Cornus / Estrés del Retículo Endoplásmico / Furaldehído Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article

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