Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.

Vasconcelos, Bruno; Stancu, Ilie-Cosmin; Buist, Arjan; Bird, Matthew; Wang, Peng; Vanoosthuyse, Alexandre; Van Kolen, Kristof; Verheyen, An; Kienlen-Campard, Pascal; Octave, Jean-Noël; Baatsen, Peter; Moechars, Diederik; Dewachter, Ilse

Vasconcelos, Bruno; Stancu, Ilie-Cosmin; Buist, Arjan; Bird, Matthew; Wang, Peng; Vanoosthuyse, Alexandre; Van Kolen, Kristof; Verheyen, An; Kienlen-Campard, Pascal; Octave, Jean-Noël; Baatsen, Peter; Moechars, Diederik; Dewachter, Ilse.

Vasconcelos B; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Stancu IC; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Buist A; Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium.
Bird M; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Wang P; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Vanoosthuyse A; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Van Kolen K; Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium.
Verheyen A; Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium.
Kienlen-Campard P; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Octave JN; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium.
Baatsen P; VIB11 vzw Center for the Biology of Disease, KU Leuven, 3000, Leuven, Belgium.
Moechars D; Department of Neuroscience, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium.
Dewachter I; Alzheimer Dementia Group, Institute of Neuroscience, Catholic University of Louvain, 1200, Brussels, Belgium. ilse.dewachter@uclouvain.be.

Acta Neuropathol ; 131(4): 549-69, 2016 Apr.

Article en En | MEDLINE | ID: mdl-26739002

Asunto(s)

Péptidos beta-Amiloides/metabolismo; Proteínas Priónicas/metabolismo; Agregación Patológica de Proteínas/metabolismo; Tauopatías/metabolismo; Proteínas tau/metabolismo; Péptidos beta-Amiloides/genética; Péptidos beta-Amiloides/toxicidad; Análisis de Varianza; Animales; Modelos Animales de Enfermedad; Proteínas Fluorescentes Verdes/genética; Proteínas Fluorescentes Verdes/metabolismo; Células HEK293; Humanos; Inmunohistoquímica; Ratones Transgénicos; Mutación/genética; Presenilina-1/genética; Presenilina-1/metabolismo; Proteínas Priónicas/ultraestructura; Agregación Patológica de Proteínas/inducido químicamente; Agregación Patológica de Proteínas/patología; Tauopatías/genética; Transfección; Proteínas tau/genética; Proteínas tau/ultraestructura

Palabras clave

Alzheimer's disease; Amyloid beta; Heterotypic seeding; Prion-like; Tau

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Proteínas tau / Tauopatías / Agregación Patológica de Proteínas / Proteínas Priónicas Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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