Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.

Stacey, Simon N; Kehr, Birte; Gudmundsson, Julius; Zink, Florian; Jonasdottir, Aslaug; Gudjonsson, Sigurjon A; Sigurdsson, Asgeir; Halldorsson, Bjarni V; Agnarsson, Bjarni A; Benediktsdottir, Kristrun R; Aben, Katja K H; Vermeulen, Sita H; Cremers, Ruben G; Panadero, Angeles; Helfand, Brian T; Cooper, Phillip R; Donovan, Jenny L; Hamdy, Freddie C; Jinga, Viorel; Okamoto, Ichiro; Jonasson, Jon G; Tryggvadottir, Laufey; Johannsdottir, Hrefna; Kristinsdottir, Anna M; Masson, Gisli; Magnusson, Olafur T; Iordache, Paul D; Helgason, Agnar; Helgason, Hannes; Sulem, Patrick; Gudbjartsson, Daniel F; Kong, Augustine; Jonsson, Eirikur; Barkardottir, Rosa B; Einarsson, Gudmundur V; Rafnar, Thorunn; Thorsteinsdottir, Unnur; Mates, Ioan N; Neal, David E; Catalona, William J; Mayordomo, José I; Kiemeney, Lambertus A; Thorleifsson, Gudmar; Stefansson, Kari

Stacey, Simon N; Kehr, Birte; Gudmundsson, Julius; Zink, Florian; Jonasdottir, Aslaug; Gudjonsson, Sigurjon A; Sigurdsson, Asgeir; Halldorsson, Bjarni V; Agnarsson, Bjarni A; Benediktsdottir, Kristrun R; Aben, Katja K H; Vermeulen, Sita H; Cremers, Ruben G; Panadero, Angeles; Helfand, Brian T; Cooper, Phillip R; Donovan, Jenny L; Hamdy, Freddie C; Jinga, Viorel; Okamoto, Ichiro; Jonasson, Jon G; Tryggvadottir, Laufey; Johannsdottir, Hrefna; Kristinsdottir, Anna M; Masson, Gisli; Magnusson, Olafur T; Iordache, Paul D; Helgason, Agnar; Helgason, Hannes; Sulem, Patrick; Gudbjartsson, Daniel F; Kong, Augustine; Jonsson, Eirikur; Barkardottir, Rosa B; Einarsson, Gudmundur V; Rafnar, Thorunn; Thorsteinsdottir, Unnur; Mates, Ioan N; Neal, David E; Catalona, William J; Mayordomo, José I; Kiemeney, Lambertus A; Thorleifsson, Gudmar; Stefansson, Kari.

Stacey SN; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, simon.stacey@decode.is kari.stefansson@decode.is.
Kehr B; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Gudmundsson J; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Zink F; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Jonasdottir A; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Gudjonsson SA; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Sigurdsson A; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Halldorsson BV; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, Institute of Biomedical and Neural Engineering, School of Science and Engineering, Reykjavik University, 101 Reykjavik, Iceland.
Agnarsson BA; Landspitali-University Hospital, IS-101 Reykjavik, Iceland, Faculty of Medicine.
Benediktsdottir KR; Landspitali-University Hospital, IS-101 Reykjavik, Iceland, Faculty of Medicine.
Aben KK; Netherlands Comprehensive Cancer Organisation, 3501GD Utrecht, The Netherlands, Radboud University Medical Center, Radboud Institute for Health Sciences, 6500HB Nijmegen, The Netherlands.
Vermeulen SH; Radboud University Medical Center, Radboud Institute for Health Sciences, 6500HB Nijmegen, The Netherlands.
Cremers RG; Radboud University Medical Center, Radboud Institute for Health Sciences, 6500HB Nijmegen, The Netherlands.
Panadero A; Division of Medical Oncology, Ciudad de Coria Hospital, 10800 Coria, Spain.
Helfand BT; Division of Urology, NorthShore University Health System, Evanston, IL 60201, USA.
Cooper PR; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Donovan JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Hamdy FC; Nuffield Department of Surgical Science, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Jinga V; University of Medicine and Pharmacy Carol Davila, Theodore Burghele Urology Clinic, Str. Dionisie Lupu, No.37, 020021 Bucharest, Romania.
Okamoto I; Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Jonasson JG; Landspitali-University Hospital, IS-101 Reykjavik, Iceland, Faculty of Medicine, Icelandic Cancer Registry, Skogarhlid 8, 105 Reykjavik, Iceland.
Tryggvadottir L; Icelandic Cancer Registry, Skogarhlid 8, 105 Reykjavik, Iceland.
Johannsdottir H; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Kristinsdottir AM; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Masson G; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Magnusson OT; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Iordache PD; Institute of Biomedical and Neural Engineering, School of Science and Engineering, Reykjavik University, 101 Reykjavik, Iceland.
Helgason A; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, Department of Anthropology and.
Helgason H; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland.
Sulem P; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Gudbjartsson DF; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland.
Kong A; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Jonsson E; Landspitali-University Hospital, IS-101 Reykjavik, Iceland, Faculty of Medicine.
Barkardottir RB; Landspitali-University Hospital, IS-101 Reykjavik, Iceland, Faculty of Medicine.
Einarsson GV; Landspitali-University Hospital, IS-101 Reykjavik, Iceland, Faculty of Medicine.
Rafnar T; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Thorsteinsdottir U; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, Faculty of Medicine.
Mates IN; University of Medicine and Pharmacy Carol Davila, St Mary General Surgical Clinic, Blv. I. Mihalache 29-43, 011172 Bucharest, Romania.
Neal DE; Nuffield Department of Surgical Science, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK, Oncology Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK and.
Catalona WJ; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Mayordomo JI; Division of Medical Oncology, University of Colorado, Aurora, CO 80045, USA.
Kiemeney LA; Radboud University Medical Center, Radboud Institute for Health Sciences, 6500HB Nijmegen, The Netherlands.
Thorleifsson G; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland.
Stefansson K; deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, Faculty of Medicine, simon.stacey@decode.is kari.stefansson@decode.is.

Hum Mol Genet ; 25(5): 1008-18, 2016 Mar 01.

Article en En | MEDLINE | ID: mdl-26740556

Asunto(s)

Neoplasias de la Mama/genética; Carcinoma Basocelular/genética; Caspasa 8/genética; Neoplasias de la Próstata/genética; Empalme del ARN; Retroelementos; Neoplasias Cutáneas/genética; Adulto; Anciano; Anciano de 80 o más Años; Alelos; Secuencia de Bases; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Carcinoma Basocelular/metabolismo; Carcinoma Basocelular/patología; Caspasa 8/metabolismo; Femenino; Estudio de Asociación del Genoma Completo; Humanos; Intrones; Masculino; Persona de Mediana Edad; Datos de Secuencia Molecular; Oportunidad Relativa; Polimorfismo de Nucleótido Simple; Neoplasias de la Próstata/metabolismo; Neoplasias de la Próstata/patología; Neoplasias de la Próstata/prevención & control; Factores Protectores; Neoplasias Cutáneas/metabolismo; Neoplasias Cutáneas/patología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias Cutáneas / Neoplasias de la Mama / Carcinoma Basocelular / Empalme del ARN / Retroelementos / Caspasa 8 Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article

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