Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.

Chen, Wei; Dong, Guoqiang; He, Shipeng; Xu, Tianying; Wang, Xia; Liu, Na; Zhang, Wannian; Miao, Chaoyu; Sheng, Chunquan

Chen, Wei; Dong, Guoqiang; He, Shipeng; Xu, Tianying; Wang, Xia; Liu, Na; Zhang, Wannian; Miao, Chaoyu; Sheng, Chunquan.

Chen W; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Dong G; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
He S; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Xu T; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Wang X; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Liu N; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Zhang W; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Miao C; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China. Electronic address: cymiao@smmu.edu.cn.
Sheng C; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China. Electronic address: shengcq@hotmail.com.

Bioorg Med Chem Lett ; 26(3): 765-768, 2016 Feb 01.

Article en En | MEDLINE | ID: mdl-26755394

Asunto(s)

Amidas/química; Antineoplásicos/química; Inhibidores Enzimáticos/química; Nicotinamida Fosforribosiltransferasa/antagonistas & inhibidores; Tiofenos/química; Amidas/síntesis química; Amidas/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Sitios de Unión; Dominio Catalítico; Línea Celular Tumoral; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/farmacología; Células Hep G2; Humanos; Simulación del Acoplamiento Molecular; Nicotinamida Fosforribosiltransferasa/metabolismo; Relación Estructura-Actividad

Palabras clave

Antiproliferative activity; Nampt inhibitors; Structureactivity relationship

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiofenos / Inhibidores Enzimáticos / Nicotinamida Fosforribosiltransferasa / Amidas / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

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