Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction.
Bioorg Med Chem Lett
; 26(3): 829-835, 2016 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-26778149
ABSTRACT
In present work we have designed and synthesized total twelve novel 3-(3-(1H-indol-3-yl)-3-phenylpropanoyl)-4-hydroxy-2H-chromen-2-one derivatives 13(a-l) using Ho(3+) doped CoFe2O4 nanoparticles as catalyst and evaluated for their potential antileishmanial and antioxidant activities. The compounds 13a, 13d and 13h were found to possess significant antileishmanial activity (IC50 value=95.50, 95.00 and 99.00µg/mL, respectively) when compared to the standard sodium stibogluconate (IC50=490.00 µg/mL). The compounds 13a (IC50=12.40 µg/mL), 13d (IC50=13.49 µg/mL), 13g (IC50=13.24 µg/mL) and 13l (IC50=13.74 µg/mL) had shown good antioxidant activity when compared with standards butylated hydroxy toluene (IC50=16.5 µg/mL) and ascorbic acid (IC50=12.8 µg/mL). After performing molecular docking studies, it was found that compounds 13a and 13d had potential to inhibit pteridine reductase 1 enzyme. In silico ADME pharmacokinetic parameters had shown promising results and none of the synthesized compounds had violated Lipinski's rule of five. Thus, suggesting that compounds from the present series can serve as important gateway for the design and development of new antileishmanial as well as antioxidant agent.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diseño de Fármacos
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Cumarinas
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Antiprotozoarios
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article