Comparative studies on mitochondrial electron transport chain complexes of Sitophilus zeamais treated with allyl isothiocyanate and calcium phosphide.
Pestic Biochem Physiol
; 126: 70-5, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26778437
ABSTRACT
With Sitophilus zeamais as the target organism, the present study for the first time attempted to elucidate the comparative effects between allyl isothiocyanate (AITC) and calcium phosphide (Ca3P2), exposure on mitochondrial electron transport chain (ETC.) complex I & IV and their downstream effects on enzymes relevant to reactive oxygen species (ROS). In vivo, both AITC and Ca3P2 inhibited complex I and IV with similar downstream effects. In contrast with Ca3P2, the inhibition of complex I caused by AITC was dependent on time and dose. In vitro, AITC inhibited complex IV more significantly than complex I. These results indicate that mitochondrial complex IV is the primary target of AITC, and that complex I is another potential target.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosfinas
/
Isotiocianatos
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Complejo IV de Transporte de Electrones
/
Proteínas de Insectos
/
Complejo I de Transporte de Electrón
/
Gorgojos
/
Insecticidas
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article