lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection.
Bioinformatics
; 32(10): 1552-4, 2016 05 15.
Article
en En
| MEDLINE
| ID: mdl-26803157
ABSTRACT
UNLABELLED Genome-wide association study (GWAS) of a biomarker is complicated when the assay procedure of the biomarker is restricted by a Limit of Detection (LOD). Those observations falling outside the LOD cannot be simply discarded, but should be included into the analysis by applying an appropriate statistical method. However, the problem of LOD in GWAS analysis of such biomarkers is usually overlooked. 'lodGWAS' is a flexible, easy-to-use R package that provides a simple and elegant way for GWAS analysis of such biomarkers while simultaneously accommodating the problem of LOD by applying a parametric survival analysis method. AVAILABILITY AND IMPLEMENTATION http//cran.r-project.org/web/packages/lodGWAS CONTACTS a.vaez@umcg.nl or i.m.nolte@umcg.nl SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Biomarcadores
/
Estudio de Asociación del Genoma Completo
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article